A synthetic peptide for use as a blocking control in assays to test for specificity of F8 antibody, Alternative Names: F8 control peptide, F8 antibody Blocking Peptide, Anti-F8 Blocking Peptide, coagulation factor VIII, procoagulant component Blocking Peptide, AHF Blocking Peptide, DXS1253E Blocking Peptide, F8B Blocking Peptide, F8C Blocking Peptide, FVIII Blocking Peptide, HEMA Blocking Peptide, F8, F-8, F 8, F-8 Blocking Peptide, F 8 Blocking Peptide
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.