Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Peptid
EGLN3
Reaktivität: Säugetier
Wirt: Synthetic
BP, WB, IHC
Produktnummer ABIN938515
Kurzübersicht für Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Peptid (ABIN938515)
Target
EGLN3
(Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
Spezies
Säugetier
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein-Typ
- Synthetic
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Sequenz
- FWSDRRNPHE VQPSYATRYA MTVWYFDAEE RAEAKKKFRN LTRKTESALT
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Produktmerkmale
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A synthetic peptide for use as a blocking control in assays to test for specificity of EGLN3 antibody,
Alternative Names: EGLN3 control peptide, EGLN3 antibody Blocking Peptide, Anti-EGLN3 Blocking Peptide, Egl Nine Homolog 3 Blocking Peptide, FLJ21620 Blocking Peptide, HIFPH3 Blocking Peptide, MGC125998 Blocking Peptide, MGC125999 Blocking Peptide, PHD3 Blocking Peptide
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Applikationshinweise
- Optimal conditions should be determined by the investigator
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20 °C long term.
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- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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Hintergrund
- EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
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Molekulargewicht
- 27 kDa
Target
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