Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Peptid
EGLN3
Reaktivität: Säugetier
Wirt: Synthetic
BP, WB, IHC
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- Target Alle EGLN3 Produkte
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
- Protein-Typ
- Synthetic
- Spezies
- Säugetier
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- FWSDRRNPHE VQPSYATRYA MTVWYFDAEE RAEAKKKFRN LTRKTESALT
- Produktmerkmale
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A synthetic peptide for use as a blocking control in assays to test for specificity of EGLN3 antibody,
Alternative Names: EGLN3 control peptide, EGLN3 antibody Blocking Peptide, Anti-EGLN3 Blocking Peptide, Egl Nine Homolog 3 Blocking Peptide, FLJ21620 Blocking Peptide, HIFPH3 Blocking Peptide, MGC125998 Blocking Peptide, MGC125999 Blocking Peptide, PHD3 Blocking Peptide
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- Applikationshinweise
- Optimal conditions should be determined by the investigator
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handhabung
- Avoid repeated freeze/thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C long term.
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- Target
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
- Hintergrund
- EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
- Molekulargewicht
- 27 kDa
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