GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) Peptid
GAPVD1
Reaktivität: Säugetier
Wirt: Synthetic
BP, IHC, WB
Produktnummer ABIN938336
Kurzübersicht für GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) Peptid (ABIN938336)
Target
GAPVD1
(GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
Spezies
Säugetier
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Protein-Typ
- Synthetic
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Sequenz
- FKLFSEGLFS AKLFLTATLH EPIMQLLVED EDHLETDPNK LIERFSPSQQ
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Produktmerkmale
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A synthetic peptide for use as a blocking control in assays to test for specificity of GAPVD1 antibody,
Alternative Names: GAPVD1 control peptide, GAPVD1 antibody Blocking Peptide, Anti-GAPVD1 Blocking Peptide, Gtpase Activating Protein And Vps9 Domains 1 Blocking Peptide, DKFZP434C212 Blocking Peptide, KIAA1521 Blocking Peptide, MGC138847 Blocking Peptide, MGC138848 Blocking Peptide, RAP6 Blocking Peptide
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Applikationshinweise
- Optimal conditions should be determined by the investigator
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20 °C long term.
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- GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
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Hintergrund
- GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
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Molekulargewicht
- 166 kDa
Target
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