A synthetic peptide for use as a blocking control in assays to test for specificity of NECAB3 antibody, Alternative Names: NECAB3 control peptide, NECAB3 antibody Blocking Peptide, Anti-NECAB3 Blocking Peptide, N-Terminal Ef-Hand Calcium Binding Protein 3 Blocking Peptide, APBA2BP Blocking Peptide, EFCBP3 Blocking Peptide, NIP1 Blocking Peptide, STIP3 Blocking Peptide, SYTIP2 Blocking Peptide, XB51 Blocking Peptide, dJ63M2.4 Blocking Peptide, dJ63M2.5 Blocking Peptide, NECAB3, NECAB-3, NECAB 3, NECAB-3 Blocking Peptide, NECAB 3 Blocking Peptide
Aufreinigung
The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide is removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.