A synthetic peptide for use as a blocking control in assays to test for specificity of PSMF1 antibody, Alternative Names: PSMF1 control peptide, PSMF1 antibody Blocking Peptide, Anti-PSMF1 Blocking Peptide, proteasome, prosome, macropain inhibitor subunit 1, PI31 Blocking Peptide, PI31 Blocking Peptide, PSMF1, PSMF-1, PSMF 1, PSMF-1 Blocking Peptide, PSMF 1 Blocking Peptide
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.