Non-POU Domain Containing, Octamer-Binding (NONO) Peptid
NONO
Reaktivität: Säugetier
Wirt: Synthetic
BP, WB, IHC
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- Target Alle NONO Produkte
- NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
- Protein-Typ
- Synthetic
- Spezies
- Säugetier
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- DGTLGLTPPT TERFGQAATM EGIGAIGGTP PAFNRAAPGA EFAPNKRRRY
- Produktmerkmale
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A synthetic peptide for use as a blocking control in assays to test for specificity of NONO antibody,
Alternative Names: NONO control peptide, NONO antibody Blocking Peptide, Anti-NONO Blocking Peptide, Non-Pou Domain Containing Octamer-Binding Blocking Peptide - Aufreinigung
- The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
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- Applikationshinweise
- Optimal conditions should be determined by the investigator
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handhabung
- Avoid repeated freeze/thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C long term.
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- Target
- NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
- Hintergrund
- NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
- Molekulargewicht
- 52 kDa
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