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Ligase IV, DNA, ATP-Dependent (LIG4) Peptid

LIG4 Reaktivität: Säugetier Wirt: Synthetic BP, IHC, WB
Produktnummer ABIN937334
  • Target Alle LIG4 Produkte
    LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
    Protein-Typ
    Synthetic
    Spezies
    Säugetier
    Quelle
    • 3
    Synthetic
    Applikation
    Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
    Sequenz
    DGERMQMHKD GDVYKYFSRN GYNYTDQFGA SPTEGSLTPF IHNAFKADIQ
    Produktmerkmale
    A synthetic peptide for use as a blocking control in assays to test for specificity of LIG4 antibody,
    Alternative Names: LIG4 control peptide, LIG4 antibody Blocking Peptide, Anti-LIG4 Blocking Peptide, Ligase Iv Dna Atp-Dependent Blocking Peptide, LIG4, LIG-4, LIG 4, LIG-4 Blocking Peptide, LIG 4 Blocking Peptide
  • Applikationshinweise
    Optimal conditions should be determined by the investigator
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
    Buffer
    PBS
    Handhabung
    Avoid repeated freeze/thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C long term.
  • Target
    LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
    Hintergrund
    LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome.
    Molekulargewicht
    104 kDa
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