A synthetic peptide for use as a blocking control in assays to test for specificity of NAT2 antibody, Alternative Names: NAT2 control peptide, NAT2 antibody Blocking Peptide, Anti-NAT2 Blocking Peptide, N-Acetyltransferase 2 Blocking Peptide, Arylamine N-Acetyltransferase Blocking Peptide, AAC2 Blocking Peptide, NAT2, NAT-2, NAT 2, NAT-2 Blocking Peptide, NAT 2 Blocking Peptide
Aufreinigung
The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide is removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
NAT2 is a N-acetyltransferase 2 (arylamine N-acetyltransferase 2). This enzyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in its gene are reponsible for the N-acetylation polymorphism in which human populations segregate into rapid,intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity.