Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A) Peptid
POLR3A
Reaktivität: Säugetier
Wirt: Synthetic
BP, WB, IHC
Produktnummer ABIN937013
Kurzübersicht für Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A) Peptid (ABIN937013)
Target
POLR3A
(Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A))
Spezies
Säugetier
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein-Typ
- Synthetic
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Sequenz
- AYFGQKDSVC GVSECIIMGI PMNIGTGLFK LLHKADRDPN PPKRPLIFDT
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Produktmerkmale
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A synthetic peptide for use as a blocking control in assays to test for specificity of POLR3 A antibody,
Alternative Names: POLR3A control peptide, POLR3A antibody Blocking Peptide, Anti-POLR3A Blocking Peptide, RNA Polymerase IIIA Blocking Peptide, RPC1 Blocking Peptide, RPC155 Blocking Peptide, hRPC155 Blocking Peptide, POLR3A, POLRA-3, POLRA 3, POLRA-3 Blocking Peptide, POLRA 3 Blocking Peptide
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Applikationshinweise
- Optimal conditions should be determined by the investigator
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20 °C long term.
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- POLR3A (Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A))
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Hintergrund
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3A is the largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
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Molekulargewicht
- 156 kDa
Target
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