A synthetic peptide for use as a blocking control in assays to test for specificity of RARA antibody, Alternative Names: RARA control peptide, RARA antibody Blocking Peptide, Anti-RARA Blocking Peptide, Retinoic Acid Receptor Alpha Blocking Peptide, NR1B1 Blocking Peptide, RAR Blocking Peptide
Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor, which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT, and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.