A synthetic peptide for use as a blocking control in assays to test for specificity of MCM3 antibody, Alternative Names: MCM3 control peptide, MCM3 antibody Blocking Peptide, Anti-MCM3 Blocking Peptide, Minichromosome Maintenance Complex Component 3 Blocking Peptide, HCC5 Blocking Peptide, MGC1157 Blocking Peptide, P1-MCM3 Blocking Peptide, P1.h Blocking Peptide, RLFB Blocking Peptide, MCM3, MCM-3, MCM 3, MCM-3 Blocking Peptide, MCM 3 Blocking Peptide
Aufreinigung
The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
MCM3 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.