Catechol-O-Methyltransferase (COMT) (AA 51-271) Peptid
COMT
Reaktivität: Human
Wirt: Escherichia coli (E. coli)
SDS
1 image
Produktnummer ABIN935019
Kurzübersicht für Catechol-O-Methyltransferase (COMT) (AA 51-271) Peptid (ABIN935019)
Target
COMT
(Catechol-O-Methyltransferase (COMT))
Spezies
Human
Quelle
Escherichia coli (E. coli)
Applikation
SDS-PAGE (SDS)
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Protein-Typ
- Recombinant
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Protein Region
- AA 51-271
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Sequenz
- MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P
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Produktmerkmale
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Purified recombinant Human COMT protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. -
Reinheit
- > 95 % pure
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Endotoxin-Niveau
- < 1.0 EU per µg of protein (determined by LAL method)
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Applikationshinweise
- COMT protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, containing 0 mM MgCl2, and 10 % glycerol.
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- RT/-20 °C
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Informationen zur Lagerung
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- COMT (Catechol-O-Methyltransferase (COMT))
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Hintergrund
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Catechol-O-methyltrasferase (COMT) is an enzyme that catalyses the transfer of the methyl group of S-adenosylmethionine (SAM) into catechol substrates such as levodopa, dopamine, epinephrine, and norepinephirine in the presence of Mg2+. COMT appears to be located in the postsynaptic neuron and plays roles in the metabolism of catechol estrogens and the inactivation of catecholamine neurotransmitters though enzymatic degradation. COMT inhibitors prevent levodopa degradation, increase its availability and are used in the treatment of patients with Parkinson's disease. Recombinant human COMT protein was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: Catechol-O-methyltransferase protein, COMT, Catechol-O-methyltransferase protein -
Molekulargewicht
- 24.4 kDa (221 AA)
Target
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