zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (N-Term) Peptid
Kurzübersicht für zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (N-Term) Peptid (ABIN8116061)
Target
Spezies
Quelle
Applikation
-
-
Protein Region
- N-Term
-
Verwendungszweck
- ZAP70 Peptide - N-terminal region
-
Sequenz
- MRKKQIDVAI KVLKQGTEKA DTEEMMREAQ IMHQLDNPYI VRLIGVCQAE
-
-
-
-
Applikationshinweise
- Optimal working dilution should be determined by the investigator.
-
Kommentare
-
This is a synthetic peptide designed for use in combination with anti-ZAP70 Antibody (ARP61186_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Buffer
- Lyophilized powder
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
-
-
- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
-
Hintergrund
-
Background Information: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Alternative Symbols: FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
-
Molekulargewicht
- 34kDa
-
Gen-ID
- 7535
-
NCBI Accession
- NP_997402
-
UniProt
- P43403
Target
-
