Ubiquitin Specific Peptidase 10 (USP10) (C-Term) Peptid
Kurzübersicht für Ubiquitin Specific Peptidase 10 (USP10) (C-Term) Peptid (ABIN8115179)
Target
Spezies
Quelle
Applikation
-
-
Protein Region
- C-Term
-
Verwendungszweck
- Usp10 Peptide - C-terminal region
-
Sequenz
- RDIRPGAAFE PTYIYRLLTV IKSSLSEKGR QEDAEEYLGF ILNGLHEEML
-
-
-
-
Applikationshinweise
- Optimal working dilution should be determined by the investigator.
-
Kommentare
-
This is a synthetic peptide designed for use in combination with anti-Usp10 Antibody (ARP59301_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Buffer
- Lyophilized powder
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
-
-
- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
-
Hintergrund
-
Background Information: Usp10 is a hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. It acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Usp10 does not deubiquitinate MDM2 and deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
Alternative Symbols: MGC124997
-
Molekulargewicht
- 87kDa
-
Gen-ID
- 307905
-
NCBI Accession
- NP_001029318
-
UniProt
- Q3KR59
Target
-
