Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (C-Term) Peptid
Kurzübersicht für Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (C-Term) Peptid (ABIN8115167)
Target
Quelle
Applikation
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Protein Region
- C-Term
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Verwendungszweck
- UBR2 Peptide - C-terminal region
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Kommentare
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This is a synthetic peptide designed for use in combination with anti-UBR2 antibody ( ARP43188_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))
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Hintergrund
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Background Information: Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron.Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM].
Alternative Symbols: C6orf133, DKFZp686C08114, KIAA0349, MGC71112, RP3-392M17.3, bA49A4.1, dJ242G1.1, dJ392M17.3
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Molekulargewicht
- 200kDa
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Gen-ID
- 23304
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NCBI Accession
- NP_056070
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UniProt
- Q8IWV8
Target
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