serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) Peptid
Kurzübersicht für serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) Peptid (ABIN8111351)
Target
Quelle
Applikation
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Verwendungszweck
- SPTLC1 Peptide
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Kommentare
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This is a synthetic peptide designed for use in combination with anti-SPTLC1 antibody ( ARP46721_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- SPTLC1 (serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1))
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Hintergrund
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Background Information: Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPTLC1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 gene were identified in patients with hereditary sensory neuropathy type 1.Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
Alternative Symbols: HSAN, HSAN1, HSN1, LBC1, LCB1, MGC14645, SPT1, SPTI, hLCB1
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Molekulargewicht
- 53kDa
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Gen-ID
- 10558
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NCBI Accession
- NP_006406
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UniProt
- O15269
Target
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