Paired-Like Homeobox 2b (PHOX2B) (C-Term) Peptid
Kurzübersicht für Paired-Like Homeobox 2b (PHOX2B) (C-Term) Peptid (ABIN8107576)
Target
Spezies
Quelle
Applikation
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Protein Region
- C-Term
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Verwendungszweck
- PHOX2B Peptide - C-terminal region
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Sequenz
- RAAAAAAAAA KNGSSGKKSD SSRDDESKEA KSTDPDSTGG PGPNPNPTPS
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Kommentare
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This is a synthetic peptide designed for use in combination with anti-PHX2B Antibody (ARP74127_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- PHOX2B (Paired-Like Homeobox 2b (PHOX2B))
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Hintergrund
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Background Information: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.
Alternative Symbols: CCHS, PMX2B, NBLST2, NBPhox
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Molekulargewicht
- 34kDa
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Gen-ID
- 8929
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NCBI Accession
- NP_003915
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UniProt
- Q99453
Target
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