Importin 5 (IPO5) (N-Term) Peptid
Kurzübersicht für Importin 5 (IPO5) (N-Term) Peptid (ABIN8102994)
Target
Spezies
Quelle
Applikation
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Protein Region
- N-Term
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Verwendungszweck
- IPO5 Peptide - N-terminal region
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Sequenz
- EDEDWANADE LEDDDFDSNA VAGESALDRM ACGLGGKLVL PMIKEHIMQM
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Kommentare
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This is a synthetic peptide designed for use in combination with anti-IPO5 Antibody (ARP74965_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- Importin 5 (IPO5)
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Hintergrund
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Background Information: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
Alternative Symbols: IPO5,KPNB3, RANBP5,
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Molekulargewicht
- 120kDa
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Gen-ID
- 3843
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UniProt
- O00410
Target
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