Axin 1 (AXIN1) (N-Term) Peptid
Kurzübersicht für Axin 1 (AXIN1) (N-Term) Peptid (ABIN8095335)
Target
Spezies
Quelle
Applikation
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Protein Region
- N-Term
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Verwendungszweck
- Axin1 Peptide - N-terminal region
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Sequenz
- Synthetic peptide located within the following region: < a href='http://www.ncbi.nlm.nih.gov/blast/Blast.cgi?PROGRAM=blastp&CLIENT=web&SERVICE=plain&PAGE=Proteins&CMD=Put&DATABASE=nr&CDD_SEARCH=1&AUTO_FORMAT=Semi-auto&SHOW_OVERVIEW=on&SHOW_LINKOUT=on&GET_SEQUENCE=on&NCBI_GI=on&ALIGNMENTS =50&I_THRESH=0.005&QUERY=
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Kommentare
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This is a synthetic peptide designed for use in combination with anti-Axin1 Antibody (ARP42875_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- Axin (AXIN1) (Axin 1 (AXIN1))
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Hintergrund
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Background Information: Axin1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Axin1 controls dorsoventral patterning via two opposing effects, down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. It also facilitates the phosphorylation of APC by GSK3B, facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation and enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7.
Alternative Symbols: AI316800, Axin, Fu, Kb, Ki, fused, kinky, knobbly
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Molekulargewicht
- 110kDa
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Gen-ID
- 12005
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NCBI Accession
- XP_920000
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UniProt
- O70239
Target
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