Apelin Receptor (APLNR) (N-Term) Peptid
Kurzübersicht für Apelin Receptor (APLNR) (N-Term) Peptid (ABIN8094786)
Target
Spezies
Quelle
Applikation
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Protein Region
- N-Term
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Verwendungszweck
- APLNR Peptide - N-terminal region
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Sequenz
- LAKLKKKKGP STVTDLEDTK RDRSVDVNGG PEPAPASTSA VSTPSPSADL
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Kommentare
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This is a synthetic peptide designed for use in combination with anti-APLNR Antibody (ARP59985_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- Apelin Receptor (APLNR)
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Hintergrund
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Targeted Subunit: alpha-2
Background Information: AP2A2 is a component of the adaptor protein complex 2 (AP-2). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif .
Alternative Symbols: AGTRL1, APJ, APJR, FLJ90771, FLJ96609, HG11, MGC45246
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Molekulargewicht
- 104kDa
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Gen-ID
- 187
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NCBI Accession
- NP_005152
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UniProt
- P35414
Target
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