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MmTx1 Toxin peptide (Atto 488)

Reaktivität: Micrurus mipartitus Wirt: Synthetic FACS, IF, LCI

MmTx1 Toxin binds to rat cerebellum. (MmTx1 Toxin peptide (Atto 488))

A) Anti-GABA(A) α1 Receptor (extracellular) Antibody (ABIN7043183) was applied, 1:100, for overnight at 4ºC, followed by staining with goat anti-rabbit , resulting in orange fluorescence predominantly in GABAergic projection neurons of deep cerebellar nuclei. (MmTx1 Toxin peptide (Atto 488))

Direct flow cytometry of MmTx1 in live intact human cells expressing GABRB3. (MmTx1 Toxin peptide (Atto 488))

MmTx1 Toxin-ATTO Fluor-488 labels GABA(A) α1 receptor in rat cerebellum. (MmTx1 Toxin peptide (Atto 488))

MmTx1 Toxin-ATTO Fluor-488 modulates GABA(A) receptors expressed in Xenopus oocytes. (MmTx1 Toxin peptide (Atto 488))

MmTx1 Toxin-ATTO Fluor-488 modulates GABA(A) receptors expressed in Xenopus oocytes. (MmTx1 Toxin peptide (Atto 488))

Live cell imaging of MmTx1 Toxin-ATTO Fluor-488 in intact human cells expressing GABRB3. (MmTx1 Toxin peptide (Atto 488))

A) Anti-GABA(A) α1 Receptor (extracellular) Antibody (ABIN7043183) was applied, 1:100, for overnight at 4ºC, followed by staining with goat anti-rabbit , resulting in orange fluorescence predominantly in pyramidal neurons of hippocampus CA3 region. (MmTx1 Toxin peptide (Atto 488))

8 Abbildungen

Produktnummer ABIN7582257

568,46 €

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Lieferung nach: Deutschland

Lieferung in 8 bis 9 Werktagen

Kurzübersicht für MmTx1 Toxin peptide (Atto 488) (ABIN7582257)

Target

MmTx1 Toxin

Spezies

Micrurus mipartitus

Quelle

Synthetic

Applikation

Flow Cytometry (FACS), Immunofluorescence (IF), Live Cell Imaging (LCI)

Protein-Typ

Synthetic

Biologische Aktivität

Active

Aufreinigungstag / Konjugat

Atto 488

Verwendungszweck

MmTx1 Toxin-ATTO Fluor-488

Sequenz

LTCKTCPFTT CPNSESCPGG QSICYQRKWE EHRGERIERR CVANCPAFGS HDTSLLCCTR DNCN-OH

Spezifität

Toxin target: GABA(A) receptors

Produktmerkmale

ATTO 488 (Ex/Em: 500/520 nm). The extent of labeling is one molecule of dye per MmTx1 Toxin molecule, linked via primary amines.

Biological Activity Comment

MmTx1 is a potent allosteric modulator of GABA(A) receptors1.
Applikationshinweise

Antigen Preadsorption Control: 200 - 400 nM

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Lyophilized

Rekonstitution

Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial and dissolve by gently tapping, tilting, or rolling the vial. Avoid vigorous vortexing, a brief, light vortex of 1-2 seconds is acceptable if necessary. Note: The product is typically supplied in a 0.5 mL conical vial. The product is readily soluble in high-quality pure water at micromolar to millimolar concentrations (typically 5 μM to 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x the final working concentration. Divide the stock solution into small, single-use aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh working solutions just before use. Avoid multiple freeze-thaw cycles and exposure to light to maintain optimal biological activity.

Buffer

Lyophilized from double distilled water (ddH2O). May contain residual trifluoroacetate (TFA).

Handhabung

Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom,Avoid vigorous vortexing. protect from moisture,keep the vial protected from light

Lagerung

-20 °C

Informationen zur Lagerung

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store at -20°C, protect from moisture, and keep the vial protected from light.
Target

MmTx1 Toxin

Hintergrund

A fluorescent probe for imaging and sensitive detection of GABA(A) receptors

Molekulargewicht

~7775 Da

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