omega-Conotoxin SVIB Peptid
Reaktivität: Conus striatus (Striated cone)
Wirt: Synthetic
BP
1 image
Produktnummer ABIN7582152
546,92 €
Zzgl. Versandkosten 20,00 € und MwSt
Lieferung nach:
Deutschland
Lieferung in 8 bis 9 Werktagen
Kurzübersicht für omega-Conotoxin SVIB Peptid (ABIN7582152)
Target
omega-Conotoxin SVIB
Spezies
Conus striatus (Striated cone)
Quelle
Synthetic
Applikation
Blocking Peptide (BP)
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Protein-Typ
- Synthetic
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Verwendungszweck
- A Potent Blocker of N-Type CaV Channels
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Sequenz
- CKLKGQSCRK TSYDCCSGSC GRSGKC-NH2
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Spezifität
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Toxin target: N-Type CaV channels,
Disulfide bonds between: Cys1-Cys16, Cys8-Cys20, and Cys15-Cys26 Cys26 - C-terminal amidation -
Produktmerkmale
- A Potent Blocker of N-Type CaV Channels
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Reinheit
- ≥98 % (HPLC)
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Applikationshinweise
- Antigen Preadsorption Control: 10 - 50 nM
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 μM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
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Buffer
- Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
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- omega-Conotoxin SVIB
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Hintergrund
- SNX-183,ω-Conotoxin SVIB, an analogue of ω-conotoxin GVIA, is a peptide toxin originally isolated from Conus striatus venoM It is a potent blocker of N-type voltage-gated Ca2+ channels. It has an analgesic effect and is being used as a potential drug for the treatment of chronic and neuropathic pain models1,2.ω-Conotoxins are disulfide-rich peptides comprises 24-31 amino acids, isolated from the venom of marine predatory cone snails. These conotoxins have a high content of basic amino acid residue and a common cysteine scaffold that stabilizes the four-loop framework2,3.Voltage-gated N-Type Ca2+ channels are predominantly expressed in nerve terminals and are involved in the regulation of neuronal excitability and nociceptive signals. These channels play an important role in the transduction of acute and chronic pain perception. They are able to transduce electrical activity into other cellular functions and regulate calcium homeostasis3.
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Molekulargewicht
- 2739 Da
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UniProt
- P28881
Target
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