Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) (N-Term) Peptid
Kurzübersicht für Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) (N-Term) Peptid (ABIN5673676)
Target
Spezies
Quelle
Applikation
-
-
Protein Region
- N-Term
-
Sequenz
- MEQEPQNGEP AEIKIIREAY KKAFLFVNKG LNTDELGQKE EAKNYYKQGI
-
Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- SPG20 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
-
-
-
Applikationshinweise
- Optimal working dilution should be determined by the investigator.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))
-
Hintergrund
-
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).
Alias Symbols: SPARTIN, TAHCCP1
Protein Size: 666 -
Gen-ID
- 23111
-
NCBI Accession
- NM_001142294, NP_001135766
-
UniProt
- Q8N0X7
Target
-