Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (Middle Region) Peptid
SNRPN
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle SNRPN Produkte
- SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
- Protein Region
- Middle Region
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- TASIAGAPTQ YPPGRGTPPP PVGRATPPPG IMAPPPGMRP PMGPPIGLPP
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- SNRPN Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
- Hintergrund
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This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome.
Alias Symbols: SMN, PWCR, SM-D, sm-N, RT-LI, HCERN3, SNRNP-N, SNURF-SNRPN
Protein Size: 240 - Gen-ID
- 6638
- NCBI Accession
- NM_003097, NP_003088
- UniProt
- P63162
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