Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (Middle Region) Peptid
IDH1
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN5673123
150,78 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 22 Werktagen
Kurzübersicht für Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (Middle Region) Peptid (ABIN5673123)
Target
IDH1
(Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- EAAHGTVTRH YRMYQKGQET STNPIASIFA WTRGLAHRAK LDNNKELAFF
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- IDH1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))
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Hintergrund
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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alias Symbols: IDH, IDP, IDCD, IDPC, PICD, HEL-216, HEL-S-26
Protein Size: 414 -
Gen-ID
- 3417
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NCBI Accession
- NM_001282386, NP_001269315
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UniProt
- O75874
Target
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