FIP1 Like 1 (FIP1L1) (N-Term) Peptid
FIP1L1
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle FIP1L1 Produkte
- FIP1L1 (FIP1 Like 1 (FIP1L1))
- Protein Region
- N-Term
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- GIEDETAENG VPKPKVTETE DDSDSDSDDD EDDVHVTIGD IKTGAPQYGS
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- FIP1L1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FIP1L1 (FIP1 Like 1 (FIP1L1))
- Hintergrund
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This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Alias Symbols: Rhe, FIP1, hFip1
Protein Size: 594 - Gen-ID
- 81608
- NCBI Accession
- NM_001134937, NP_001128409
- UniProt
- Q6UN15
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