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FIP1 Like 1 (FIP1L1) (N-Term) Peptid

FIP1L1 Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN5673068
  • Target Alle FIP1L1 Produkte
    FIP1L1 (FIP1 Like 1 (FIP1L1))
    Protein Region
    N-Term
    Spezies
    Human
    Quelle
    • 3
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    GIEDETAENG VPKPKVTETE DDSDSDSDDD EDDVHVTIGD IKTGAPQYGS
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti- FIP1L1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    FIP1L1 (FIP1 Like 1 (FIP1L1))
    Hintergrund
    This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

    Alias Symbols: Rhe, FIP1, hFip1

    Protein Size: 594
    Gen-ID
    81608
    NCBI Accession
    NM_001134937, NP_001128409
    UniProt
    Q6UN15
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