Caspase 8 (CASP8) (C-Term) Peptid
CASP8
Reaktivität: Human
Wirt: Synthetic
BP, WB
Kurzübersicht für Caspase 8 (CASP8) (C-Term) Peptid (ABIN5673019)
Target
Caspase 8 (CASP8)
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequenz
- SLRERCPRGD DILTILTEVN YEVSNKDDKK NMGKQMPQPT FTLRKKLVFP
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- CASP8 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Caspase 8 (CASP8)
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Hintergrund
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This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Alias Symbols: CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8
Protein Size: 496 -
Gen-ID
- 841
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NCBI Accession
- NM_001080124, NP_001073593
Target
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