Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (Middle Region) Peptid
DDB2
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle DDB2 Produkte
- DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
- Protein Region
- Middle Region
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- PLNTNQFYAS SMEGTTRLQD FKGNILRVFA SSDTINIWFC SLDVSASSRM
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- DDB2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
- Hintergrund
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This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: XPE, DDBB, UV-DDB2
Protein Size: 427 - Gen-ID
- 1643
- NCBI Accession
- NM_000107, NP_000098
- UniProt
- Q92466
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