MutS Homolog 6 (E. Coli) (MSH6) (Middle Region) Peptid
MSH6
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN5671696
Kurzübersicht für MutS Homolog 6 (E. Coli) (MSH6) (Middle Region) Peptid (ABIN5671696)
Target
MSH6
(MutS Homolog 6 (E. Coli) (MSH6))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- MVVPDKISEV VELLKKLPDL ERLLSKIHNV GSPLKSQNHP DSRAIMYEET
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- MSH6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
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Hintergrund
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This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
Alias Symbols: GTBP, HSAP, p160, GTMBP, HNPCC5
Protein Size: 1360 -
Gen-ID
- 2956
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NCBI Accession
- NM_000179, NP_000170
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UniProt
- P52701
Target
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