Activating Transcription Factor 7 (ATF7) (Middle Region) Peptid
ATF7
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN5671442
Kurzübersicht für Activating Transcription Factor 7 (ATF7) (Middle Region) Peptid (ABIN5671442)
Target
ATF7
(Activating Transcription Factor 7 (ATF7))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- QILIQHPDAP SPAQPQVSPA QPTPSTGGRR RRTVDEDPDE RRQRFLERNR
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- ATF7 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Activating Transcription Factor 7 (ATF7) peptide
ATF7 Reaktivität: Human, Ratte, Rind (Kuh), Hund Wirt: Synthetic BP, Imm
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ATF7 (Activating Transcription Factor 7 (ATF7))
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Hintergrund
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Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
Alias Symbols: ATFA
Protein Size: 494 -
Gen-ID
- 11016
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NCBI Accession
- NM_001130060, NP_001123532
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UniProt
- P17544
Target
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