Cathepsin F (CTSF) (C-Term) Peptid
CTSF
Reaktivität: Human
Wirt: Synthetic
WB
Produktnummer ABIN5518531
Kurzübersicht für Cathepsin F (CTSF) (C-Term) Peptid (ABIN5518531)
Target
Cathepsin F (CTSF)
Spezies
Human
Quelle
Synthetic
Applikation
Western Blotting (WB)
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Protein Region
- C-Term
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Sequenz
- PLRPLCSPWL IDHAVLLVGY GNRSDVPFWA IKNSWGTDWG EKGYYYLHRG
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Cathepsin F (CTSF) peptide
CTSF Reaktivität: Human, Maus, Ratte, Hund Wirt: Synthetic BP, Imm
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Cathepsin F (CTSF)
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Hintergrund
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Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.
Alias Symbols: CATSF, CLN13
Protein Size: 484 -
Gen-ID
- 8722
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NCBI Accession
- NM_003793, NP_003784
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UniProt
- Q9UBX1
Target
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