Unc-13 Homolog B (UNC13B) (Middle Region) Peptid
UNC13B
Reaktivität: Human
Wirt: Synthetic
WB
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- Target Alle UNC13B Produkte
- UNC13B (Unc-13 Homolog B (UNC13B))
- Protein Region
- Middle Region
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Western Blotting (WB)
- Sequenz
- SYDLDYPERR AISPTSSSRY GSSCNVSQGS SQLSELDQYH EQDDDHRETD
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- UNC13B (Unc-13 Homolog B (UNC13B))
- Hintergrund
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This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
Alias Symbols: UNC13, MUNC13, Unc13h2
Protein Size: 1591 - Gen-ID
- 10497
- NCBI Accession
- NM_006377, NP_006368
- UniProt
- O14795
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