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Polypyrimidine Tract Binding Protein 1 (PTBP1) (N-Term) Peptid

PTBP1 Reaktivität: Human Wirt: Synthetic WB

Produktnummer ABIN5518181

Kurzübersicht für Polypyrimidine Tract Binding Protein 1 (PTBP1) (N-Term) Peptid (ABIN5518181)

Target

PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Spezies

Human

Quelle

Synthetic

Applikation

Western Blotting (WB)

Protein Region

N-Term

Sequenz

KFKGDSRSAG VPSRVIHIRK LPIDVTEGEV ISLGLPFGKV TNLLMLKGKN
Polypyrimidine Tract Binding Protein 1 (PTBP1) peptide
PTBP1 Reaktivität: Human, Rind (Kuh), Hund, Maus, Schwein, Ratte Wirt: Synthetic BP, Imm

Polypyrimidine Tract Binding Protein 1 (PTBP1) peptide
PTBP1 Wirt: Synthetic BP, WB, IHC

Polypyrimidine Tract Binding Protein 1 (PTBP1) peptide
PTBP1 Reaktivität: Säugetier Wirt: Synthetic BP, WB, IHC

Polypyrimidine Tract Binding Protein 1 (PTBP1) (N-Term) peptide
PTBP1 Reaktivität: Human Wirt: Synthetic BP, WB

Polypyrimidine Tract Binding Protein 1 (PTBP1) (Middle Region) peptide
PTBP1 Reaktivität: Human Wirt: Synthetic BP, WB

Polypyrimidine Tract Binding Protein 1 (PTBP1) peptide
PTBP1 Reaktivität: Human Wirt: Synthetic BP, WB

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Lyophilized

Rekonstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Lagerung

-20 °C

Informationen zur Lagerung

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Hintergrund

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Alias Symbols: PTB, PTB2, PTB3, PTB4, pPTB, HNRPI, PTB-1, PTB-T, HNRNPI, HNRNP-I

Protein Size: 167

Gen-ID

5725

NCBI Accession

NM_002819, NP_002810

UniProt

P26599

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