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Polypyrimidine Tract Binding Protein 1 (PTBP1) (N-Term) Peptid

PTBP1 Reaktivität: Human Wirt: Synthetic WB
Produktnummer ABIN5518181
  • Target Alle PTBP1 Produkte
    PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))
    Protein Region
    N-Term
    Spezies
    Human
    Quelle
    • 6
    Synthetic
    Applikation
    Western Blotting (WB)
    Sequenz
    KFKGDSRSAG VPSRVIHIRK LPIDVTEGEV ISLGLPFGKV TNLLMLKGKN
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))
    Hintergrund
    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

    Alias Symbols: PTB, PTB2, PTB3, PTB4, pPTB, HNRPI, PTB-1, PTB-T, HNRNPI, HNRNP-I

    Protein Size: 167
    Gen-ID
    5725
    NCBI Accession
    NM_002819, NP_002810
    UniProt
    P26599
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