Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (Middle Region) Peptid
GEMIN2
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN5513379
Kurzübersicht für Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (Middle Region) Peptid (ABIN5513379)
Target
SIP1 (GEMIN2)
(Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- QQQQVAQFST VRQNVNKHRS HWKSQQLDSN VTMPKSEDEE GWKKFCLGEK
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- SIP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))
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Hintergrund
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This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Alias Symbols: SIP1, SIP1-delta
Protein Size: 280 -
Gen-ID
- 8487
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NCBI Accession
- NM_001009182, NP_001009182
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UniProt
- O14893
Target
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