Damage Specific DNA Binding Protein 1 (DDB1) (Middle Region) Peptid
DDB1
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN5511965
Kurzübersicht für Damage Specific DNA Binding Protein 1 (DDB1) (Middle Region) Peptid (ABIN5511965)
Target
DDB1
(Damage Specific DNA Binding Protein 1 (DDB1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- IGIHEHASID LPGIKGLWPL RSDPNRETDD TLVLSFVGQT RVLMLNGEEV
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-DDB1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Damage Specific DNA Binding Protein 1 (DDB1) peptide
DDB1 Reaktivität: Human, Maus, Rind (Kuh), Hund, Ratte Wirt: Synthetic BP, Imm
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
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Hintergrund
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The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
Alias Symbols: DDB1,XAP1,
Protein Size: 1140 -
Gen-ID
- 1642
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NCBI Accession
- XP_005273861
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UniProt
- Q16531
Target
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