Ubiquitin Interaction Motif Containing 1 (UIMC1) (Middle Region) Peptid
UIMC1
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle UIMC1 Produkte
- UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
- Protein Region
- Middle Region
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- GIPFCPDGVD PNQYTKVILC QLEVYQKSLK MAQRQLLNKK GFGEPVLPRP
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-UIMC1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
- Synonyme
- UIMC1 Peptide, RAP80 Peptide, X2HRIP110 Peptide, 9430016E08Rik Peptide, D330018D10Rik Peptide, D630032M02Rik Peptide, RIP110 Peptide, Rxrip110 Peptide, RGD1307009 Peptide, ubiquitin interaction motif containing 1 Peptide, UIMC1 Peptide, Uimc1 Peptide
- Hintergrund
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UIMC1 is a ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. It also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. It may interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. And it may indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Alias Symbols: UIMC1,RAP80, RXRIP110,
Protein Size: 641 - Gen-ID
- 51720
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