Makorin Ring Finger Protein 1 (MKRN1) Peptid
MKRN1
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN5511368
Kurzübersicht für Makorin Ring Finger Protein 1 (MKRN1) Peptid (ABIN5511368)
Target
MKRN1
(Makorin Ring Finger Protein 1 (MKRN1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-MKRN1 antibody (Catalog #: ARP74642_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Makorin Ring Finger Protein 1 (MKRN1) peptide
MKRN1 Reaktivität: Human, Hund Wirt: Synthetic BP, Imm
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))
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Hintergrund
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This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: RNF61
Protein Size: 482 -
Molekulargewicht
- 53 kDa
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Gen-ID
- 23608
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NCBI Accession
- NP_038474
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UniProt
- Q9UHC7
Target
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