Myelin Oligodendrocyte Glycoprotein Peptide (AA 35-55) Peptid

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Proteinname
Protein Region
AA 35-55
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Reinigung Rabbit Anti-Pyk2 (Phospho-Tyr402) Polyclonal Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Reinheit 95 %
Proteinname
Hintergrund Myelin oligodendrocyte glycoprotein (MOG) is found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes and has been implicated as an important autoantigen in multiple sclerosis (MS). This peptide induces severe chronic experimental autoimmune encephalomyelitis in transgenic mice.
CAS-Nummer 163913-87-9
Beschränkungen Nur für Forschungszwecke einsetzbar
Lagerung -20 °C
Produkt verwendet in: Verinaud, Issayama, Zanucoli, de Carvalho, da Costa, Di Gangi, Bonfanti, Ferreira, de Oliveira, Machado, Thomé: "Nitric oxide plays a key role in the suppressive activity of tolerogenic dendritic cells." in: Cellular & molecular immunology, Vol. 12, Issue 3, pp. 384-6, 2015 (PubMed).

Marin-Bañasco, Suardíaz García, Hurtado Guerrero, Maldonado Sánchez, Estivill-Torrús, Leyva Fernández, Fernández Fernández: "Mesenchymal properties of SJL mice-stem cells and their efficacy as autologous therapy in a relapsing-remitting multiple sclerosis model." in: Stem cell research & therapy, Vol. 5, Issue 6, pp. 134, 2015 (PubMed).

Sheridan, Dev: "Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations." in: Scientific reports, Vol. 4, pp. 5051, 2014 (PubMed).

Xie, Chen, McMickle, Awar, Nady, Sredni, Drew, Yu: "The immunomodulator AS101 suppresses production of inflammatory cytokines and ameliorates the pathogenesis of experimental autoimmune encephalomyelitis." in: Journal of neuroimmunology, Vol. 273, Issue 1-2, pp. 31-41, 2014 (PubMed).

Dungan, McGuinness, Boon, Lynch, Mills: "Innate IFN-? promotes development of experimental autoimmune encephalomyelitis: a role for NK cells and M1 macrophages." in: European journal of immunology, Vol. 44, Issue 10, pp. 2903-17, 2014 (PubMed).

Khan, Dine, Luna, Ahlem, Shindler: "HE3286 reduces axonal loss and preserves retinal ganglion cell function in experimental optic neuritis." in: Investigative ophthalmology & visual science, Vol. 55, Issue 9, pp. 5744-51, 2014 (PubMed).

Thomé, Bombeiro, Issayama, Rapôso, Lopes, da Costa, Di Gangi, Ferreira, Longhini, Oliveira, da Cruz Höfling, Costa, Verinaud: "Exacerbation of autoimmune neuro-inflammation in mice cured from blood-stage Plasmodium berghei infection." in: PLoS ONE, Vol. 9, Issue 10, pp. e110739, 2014 (PubMed).

Aharoni, Sasson, Blumenfeld-Katzir, Eilam, Sela, Assaf, Arnon: "Magnetic resonance imaging characterization of different experimental autoimmune encephalomyelitis models and the therapeutic effect of glatiramer acetate." in: Experimental neurology, Vol. 240, pp. 130-44, 2013 (PubMed).

Kozela, Juknat, Kaushansky, Rimmerman, Ben-Nun, Vogel: "Cannabinoids decrease the th17 inflammatory autoimmune phenotype." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 8, Issue 5, pp. 1265-76, 2013 (PubMed).

Angiari, Rossi, Piccio, Zinselmeyer, Budui, Zenaro, Della Bianca, Bach, Scarpini, Bolomini-Vittori, Piacentino, Dusi, Laudanna, Cross, Miller, Constantin: "Regulatory T cells suppress the late phase of the immune response in lymph nodes through P-selectin glycoprotein ligand-1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 11, pp. 5489-500, 2013 (PubMed).

Heckman, DeCoteau, Estevez, Reed, Costanzo, Sanford, Leiter, Clauss, Knapp, Gomez, Mullen, Rathbun, Prime, Marini, Patchefsky, Patchefsky, Hailstone, Erlichman: "Custom cerium oxide nanoparticles protect against a free radical mediated autoimmune degenerative disease in the brain." in: ACS nano, Vol. 7, Issue 12, pp. 10582-96, 2013 (PubMed).

Kim, Srikanth, Tan, Yee, Jew, Damoiseaux, Jung, Shimizu, An, Ribalet, Waschek, Gwack: "Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 1, pp. 110-22, 2013 (PubMed).

Locatelli, Wörtge, Buch, Ingold, Frommer, Sobottka, Krüger, Karram, Bühlmann, Bechmann, Heppner, Waisman, Becher: "Primary oligodendrocyte death does not elicit anti-CNS immunity." in: Nature neuroscience, Vol. 15, Issue 4, pp. 543-50, 2012 (PubMed).

Maine, Hamilton-Williams, Cheung, Stanford, Bottini, Wicker, Sherman: "PTPN22 alters the development of regulatory T cells in the thymus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 11, pp. 5267-75, 2012 (PubMed).

Petratos, Ozturk, Azari, Kenny, Lee, Magee, Harvey, McDonald, Taghian, Moussa, Mun Aui, Siatskas, Litwak, Fehlings, Strittmatter, Bernard: "Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation." in: Brain : a journal of neurology, Vol. 135, Issue Pt 6, pp. 1794-818, 2012 (PubMed).

Aharoni, Saada, Eilam, Hayardeny, Sela, Arnon: "Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis." in: Journal of neuroimmunology, Vol. 251, Issue 1-2, pp. 14-24, 2012 (PubMed).

Siegmund, Zeis, Kunz, Rolink, Schaeren-Wiemers, Pieters: "Coronin 1-mediated naive T cell survival is essential for the development of autoimmune encephalomyelitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 6, pp. 3452-61, 2011 (PubMed).

Lalor, Dungan, Sutton, Basdeo, Fletcher, Mills: "Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 10, pp. 5738-48, 2011 (PubMed).

Codarri, Gyülvészi, Tosevski, Hesske, Fontana, Magnenat, Suter, Becher: "ROR?t drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation." in: Nature immunology, Vol. 12, Issue 6, pp. 560-7, 2011 (PubMed).

Hofmann, Mair, Greter, Schmidt-Supprian, Becher: "NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses." in: The Journal of experimental medicine, Vol. 208, Issue 9, pp. 1917-29, 2011 (PubMed).