SET Nuclear Oncogene (SET) Peptid
SET
Reaktivität: Human
Wirt: Kaninchen
BP
Produktnummer ABIN2764137
-15% Promotion 2026
199,38 €
Sparen Sie 35,18 € (-15 %)
Zzgl. Versandkosten 20,00 € und MwSt
50 μg
Lieferung nach:
Deutschland
Lieferung in 8 bis 11 Werktagen
Kurzübersicht für SET Nuclear Oncogene (SET) Peptid (ABIN2764137)
Target
SET/TAF-I (SET)
(SET Nuclear Oncogene (SET))
Spezies
Human
Quelle
Kaninchen
Applikation
Blocking Peptide (BP)
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Lagerung
- -20 °C
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- SET/TAF-I (SET) (SET Nuclear Oncogene (SET))
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Hintergrund
- Human SET was originally identified as part of the SET-CAN fusion gene produced by a somatic translocation event in a patient with acute undifferentiated leukemia. In developing kidney, SET is highly expressed in the zone of nephron morphogenesis. SET has been shown to be a potent and specific inhibitor of protein phosphatase 2A, a family of major serine/threonine phosphatases involved in regulating cell proliferation and differentiation. SET is also involved in the regulation of renal cell proliferation and tumorigenesis. SET mRNA expression is markedly reduced in cells rendered quiescent by serum starvation, contact inhibition, or differentiation. SET protein expression is also much greater in developing rat and human kidney than in fully differentiated, mature kidney. High levels of SET mRNA and SET protein expression arefound in Wilms' tumor, but not in renal cell carcinoma, adult polycystic kidney disease or in transitional cell carcinoma.
Target
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