Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1) Peptid
ROBO1
Reaktivität: Human
Wirt: Kaninchen
BP
Produktnummer ABIN2764127
Kurzübersicht für Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1) Peptid (ABIN2764127)
Target
ROBO1
(Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
Spezies
Human
Quelle
Kaninchen
Applikation
Blocking Peptide (BP)
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Lagerung
- -20 °C
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- ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
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Hintergrund
- Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line.
Target
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