Hepatitis C Virus Core Genotype-1 a recombinant protein Expression System: E.coli
Aufreinigung
Proprietary chromatographic technique
Reinheit
> 95 % pure
Applikationshinweise
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
50 mM tris-HCl, pH 8.0, with 60 mM NaCl, 10 mM glutathione, 0.25 % sarkosil and 55 % glycerol.
Handhabung
Avoid repeated freeze/thaw cycles.
Lagerung
RT/-20 °C
Target
Nucelocapsid Genoytpe 1A
Substanzklasse
Viral Protein
Hintergrund
HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6). Alternative Names: HCV protein, HCV Recombinant protein, Hep C protein, Hepatitis C protein, HCV Nucleocapsid Genoytpe 1A protein