Maternal Embryonic Leucine Zipper Kinase (MELK) (N-Term) Peptid
MELK
Reaktivität: Human, Maus
Wirt: Synthetic
BP, WB
Produktnummer ABIN2184957
Kurzübersicht für Maternal Embryonic Leucine Zipper Kinase (MELK) (N-Term) Peptid (ABIN2184957)
Target
MELK
(Maternal Embryonic Leucine Zipper Kinase (MELK))
Spezies
Human, Maus
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequenz
- GFAKVKLACH VLTGEMVAIK IMDKNALGSD LPRVKTEIDA LKSLRHQHIC
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-Melk Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Maternal Embryonic Leucine Zipper Kinase (MELK) peptide
MELK Reaktivität: Human, Maus, Rind (Kuh), Hund Wirt: Synthetic BP, Imm
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeat freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
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Hintergrund
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Melk is a Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Melk Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. It Plays a key role in cell proliferation. It is required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. It's also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus and may also play a role in primitive hematopoiesis.
Alias Symbols: AI327312, MPK38, mKIAA0175
Protein Size: 643 -
Molekulargewicht
- 70 kDa
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Gen-ID
- 17279
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NCBI Accession
- NM_010790, NP_034920
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UniProt
- Q61846
Target
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