GRB2-Related Adaptor Protein (GRAP) (N-Term) Peptid
GRAP
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle GRAP Produkte
- GRAP (GRB2-Related Adaptor Protein (GRAP))
- Protein Region
- N-Term
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- SDELAFNKGD TLKILNMEDD QNWYKAELRG VEGFIPKNYI RVKPHPWYSG
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with antiGRAP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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GRB2-Related Adaptor Protein (GRAP) peptide
GRAP Reaktivität: Human, Ratte, Rind (Kuh), Maus Wirt: Synthetic BP, Imm
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeat freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at 20C. Avoid repeat freezethaw cycles.
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- Target
- GRAP (GRB2-Related Adaptor Protein (GRAP))
- Hintergrund
-
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligandactivated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCRABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its Nterminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
Alias Symbols: -
Protein Size: 217 - Molekulargewicht
- 25 kDa
- Gen-ID
- 10750
- NCBI Accession
- NM_006613, NP_006604
- UniProt
- Q13588
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