Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) (POLR3G) (Middle Region) Peptid
POLR3G
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN1542053
150,78 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 22 Werktagen
Kurzübersicht für Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) (POLR3G) (Middle Region) Peptid (ABIN1542053)
Target
POLR3G
(Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) (POLR3G))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- SKRYMKVYKE EWIPDWRRLP REMMPRNKCK KAGPKPKKAK DAGKGTPLTN
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-POLR3G Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- POLR3G (Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) (POLR3G))
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Hintergrund
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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3G is a specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It may direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. It may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3G plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. POLR3G acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3G can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Alias Symbols: RPC32, RPC7
Protein Size: 223 -
Molekulargewicht
- 26 kDa
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Gen-ID
- 10622
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NCBI Accession
- NM_006467, NP_006458
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UniProt
- O15318
Target
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