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dSec10 has no detectable role in most forms of polarized trafficking/exocytosis, including neurotransmission, but rather is essential for endocrine secretion
The structure of zSec10 consists of tandem antiparallel helix bundles that form a straight rod, like helical core regions of other exocyst subunits.
Suggest that the exocyst sec10, acting through EGFR, endocytosis, and the MAPK pathway is a candidate therapeutic target for acute kidney injury.
knockdown of exocyst component Sec10 yields cellular phenotypes associated with Autosomal dominant polycystic kidney disease, including loss of flow-generated calcium increases, hyperproliferation, and abnormal activation of MAPK
These data confirm that the exocyst is preferentially involved in basolateral protein translation and translocation, and may well act through the phosphorylation of Sec61beta.
Exocyst Sec10 overexpression reduces damage to tubular epithelial barriers caused by hydrogen peroxide and speeds the recovery of normal epithelial barrier function after such an injury.
Data show that GTP-bound ARF6 interacts with Sec10, a subunit of the exocyst complex involved in docking of vesicles with the plasma membrane.
The exocyst protein Sec10 regulates primary ciliogenesis.
SEC10 copurifies in a high molecular mass fraction of 900 kD, interacts with SEC15b, and functions as a subunit in a exocyst complex that plays important roles in morphogenesis.
SEC-10 coordinates with RAB-10 and microtubules to form the endosomal tubular network for efficient recycling of particular clathrin-independent endocytic cargoes.
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.
, SEC10-like 1
, exocyst complex component 5
, SEC10 protein
, Exocyst complex component 5
, exocyst complex component 5-like
, exocyst complex component Sec10
, 71 kDa component of rsec6/8 secretory complex
, p71 component of rsec6/8 secretory complex