PDL1 Detection Set (Risk Free)
Kurzübersicht für PDL1 Detection Set (Risk Free) (ABIN6251785)
Target
Bindungsspezifität
Reaktivität
Wirt
Klonalität
Applikation
-
-
Marke
- Risk-Free™
-
Produktmerkmale
- Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.
-
Aufreinigung
- Antibodies are supplied as protein A purified IgG1.
-
Bestandteile
-
PD-L1 Antibody [4F2]
PD-L1 Antibody [8E12]
PD-L1 Antibody [6H10]
PD-L1 Antibody [2D6]
PD-L1 Antibody [1F11]
PD-L1 Antibody [1D7] -
Immunogen
- PD-L1 antibodies were raised against the extracellular domain of human PD-L1.
-
Isotyp
- IgG1
-
-
CD274 (Human) Matched Antibody Pair
ELISA Reaktivität: Human ELISA unconjugated Wirt: Maus
-
-
Kommentare
-
Risk-Free™ antibodies are monoclonal antibodies made to improve in vitro studies.
Unlike antibodies developed using proteins made in yeast or bacteria, Risk-Free™ antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein.
These antibodies have the following advantages:
- Antibodies are developed against mammalian-expressed, post-translationally modified recombinant proteins.
- Multiple antibodies per target allows the user to choose the best antibody for their application
- Available individually or as a set
- Risk-Free™ means they are rigorously tested and guaranteed to work for their designated applications:
- ELISA
- Flow Cytometry
- Immunoblot
- Immunohistochemistry
- Immunocytochemistry
- Immunofluorescence -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 1 mg/mL
-
Buffer
- PBS containing 0.02 % sodium azide.
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
-
- PD-L1 (CD274 (PD-L1))
-
Andere Bezeichnung
- PDL1
Target
-
