anti-Interleukin 1 alpha (IL1A) antibody pair
Kurzübersicht für anti-Interleukin 1 alpha (IL1A) antibody pair (ABIN1305225)
Target
Reaktivität
Wirt
Klonalität
Applikation
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Methodentyp
- Sandwich ELISA
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Detektionsbereich
- 15.6-2000 pg/mL
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Untere Nachweisgrenze
- 15.6 pg/mL
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Spezifität
- Detects mouse IL-1alpha.
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Keine Kreuzreaktivität
- Human
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Kreuzreaktivität (Details)
- Does not detect human IL-1alpha or mouse IL-1beta.
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Sensitivität
- 10 pg/mL
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Bestandteile
- 1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (120μg) [COAT] 1 vial detection antibody (30μg) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
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IL1A (Human) Matched Antibody Pair
ELISA Reaktivität: Human ELISA unconjugated Wirt: Kaninchen, Maus
IL1A (Human) IP-WB Antibody PairIP Reaktivität: Human IP unconjugated Wirt: Kaninchen, Maus
IL1A (Human) Matched Antibody PairELISA Reaktivität: Human ELISA unconjugated Wirt: Kaninchen, Maus
IL1A (Human) Matched Antibody PairELISA Reaktivität: Human ELISA unconjugated Wirt: Maus
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- Lot specific
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Lagerung
- -20 °C
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Informationen zur Lagerung
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Short Term Storage: -20°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
Haltbarkeit
- 12 months
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- IL1A (Interleukin 1 alpha (IL1A))
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Andere Bezeichnung
- IL-1alpha
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Hintergrund
- The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
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UniProt
- P01582
Target
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