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These data collectively indicate that Wip1 modulates host sensitivity to colitis by intrinsically regulating immune cells.
Wip1 phosphatase plays a vital role in regulating hippocampal synaptic plasticity by modulating the phosphorylation of CaMKII (zeige CAMK2G Proteine).
Findings indicate that the PPM1D-Ulk1 (zeige ULK1 Proteine) axis plays a pivotal role in genotoxic stress-induced autophagy.
This suggests an important cross-talk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for MB.
WIP1 phosphatase plays a pro-adipogenic role by interacting directly with PPARgamma (zeige PPARG Proteine) and dephosphorylating p-PPARgamma (zeige PPARG Proteine) S112 in vitro and in vivo.
this study shows that knock out of Wip1 in mouse aggravates colonic inflammation and increases neutrophils migration
the data indicate that the WIP1 phosphatase functions to maintain insulin (zeige INS Proteine) sensitivity and glucose homeostasis.
Study suggests a potential protective function of p53 (zeige TP53 Proteine)-induced phosphatase 1 in mood stabilization.
loss of Wip1 phosphatase induces a p53 (zeige TP53 Proteine)-dependent, but p21-independent, mechanism that impairs B-cell development by enhancing apoptosis in early B-cell precursors
our findings identify Wip1 as an intrinsic negative regulator of neutrophil inflammation in intestinal I/R injury process
In an in vitro model of the blood-brain barrier, LPS (zeige IRF6 Proteine) raised Wip1 expression. Wip1 knockdown increased permeability and decreased transepithelial electrical resistance, protein expression of ZO-1 (zeige TJP1 Proteine), and occluding. Wip1 silencing augmented TNF-alpha (zeige TNF Proteine), IL-1beta (zeige IL1B Proteine), IL-12 (zeige IL12A Proteine), and IL-6 (zeige IL6 Proteine). Sonic hedgehog (zeige SHH Proteine) signaling was activated by Wip1 overexpression and inhibited by silencing. Wip1 may protect the BBB against LPS (zeige IRF6 Proteine) damage via SHH (zeige SHH Proteine) signal...
Studies suugest Wip1 role in tumorigenesis through regulation of p53 (zeige TP53 Proteine) and p38MAPK (zeige MAPK14 Proteine) pathways.
The inhibition of Wip1 might fortify p53 (zeige TP53 Proteine)-mediated tumor suppression by Mdm2 (zeige MDM2 Proteine) antagonists.
Wip1 suppressed ovarian cancer cell invasion, migration, epithelial to mesenchymal transition (EMT (zeige ITK Proteine)), and ovarian cancer metastasis in xenograft animal models.
model reproduces the observed cellular phenotypes in experiments: oscillatory (for low DNA damage) regulated by negative feedback loops involving mainly p53 (zeige TP53 Proteine) and Mdm2 (zeige MDM2 Proteine) and apoptotic or senescent (for high DNA damage) regulated by the positive p53 (zeige TP53 Proteine)/Wip1/miR-16 (zeige GDE1 Proteine) feedback loop
Wip1 activity and its relevance to cancer as an oncoprotein is reviewed
The authors show that a global spread of ATM (zeige ATM Proteine) activity on chromatin and phosphorylation of ATM (zeige ATM Proteine) targets including KAP1 (zeige CDKN3 Proteine) control Plk1 re-activation. These phosphorylations are rapidly counteracted by the chromatin-bound phosphatase Wip1, allowing cell cycle restart despite persistent ATM (zeige ATM Proteine) activity present at DNA lesions.
Truncating and missense PPM1D mutations are associated with prostate cancer.
this study shows that expression of Wip1 is decreased in patients with active inflammatory bowel disease
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
, p53-induced protein phosphatase 1
, protein phosphatase 1D
, protein phosphatase 2C isoform delta
, protein phosphatase magnesium-dependent 1 delta
, protein phosphatase 1D magnesium-dependent, delta isoform
, protein phosphatase 2C delta isoform
, protein phosphatase Wip1
, wild-type p53-induced phosphatase 1