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anti-Human p300 Antikörper:
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Human Monoclonal p300 Primary Antibody für ChIP, EM - ABIN152047
Eckner, Ludlow, Lill, Oldread, Arany, Modjtahedi, DeCaprio, Livingston, Morgan: Association of p300 and CBP with simian virus 40 large T antigen. in Molecular and cellular biology 1996
Show all 9 Pubmed References
Human Monoclonal p300 Primary Antibody für FACS, ICC - ABIN151948
Eckner, Yao, Oldread, Livingston: Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. in Genes & development 1996
Show all 6 Pubmed References
Human Polyclonal p300 Primary Antibody für DB - ABIN1881299
Zhang, Zhang, Rui, Liu: p300-mediated acetylation stabilizes the Th-inducing POK factor. in Journal of immunology (Baltimore, Md. : 1950) 2010
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Human Monoclonal p300 Primary Antibody für ChIP, ICC - ABIN152048
Eckner, Ewen, Newsome, Gerdes, DeCaprio, Lawrence, Livingston: Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. in Genes & development 1994
Show all 4 Pubmed References
Human Polyclonal p300 Primary Antibody für ChIP, ICC - ABIN152981
Julien, Carriere, Moreau, Roux: mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. in Molecular and cellular biology 2010
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Human Polyclonal p300 Primary Antibody für DB, IHC (p) - ABIN537611
Jin, Jeon, Li, Lee, Choi, Kim, Lee, Bae: Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. in The Journal of biological chemistry 2004
Show all 3 Pubmed References
Human Monoclonal p300 Primary Antibody für ChIPSeq, ChIP - ABIN2668569
Dallas, Yaciuk, Moran: Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes. in Journal of virology 1997
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Human Monoclonal p300 Primary Antibody für ELISA, WB - ABIN966068
Stauffer, Chang, Huang, Dunn, Thayer: p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. in The Journal of biological chemistry 2007
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Human Monoclonal p300 Primary Antibody für ELISA, WB - ABIN969098
Geiger, Sharma, Kim, Nyborg: The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB. in Molecular and cellular biology 2008
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Human Polyclonal p300 Primary Antibody für IHC, IP - ABIN152980
Zhang, Vogel, Liu, Topark-Ngarm, Arbogast, Maier, Filtz, Leid: Coordinated regulation of transcription factor Bcl11b activity in thymocytes by the mitogen-activated protein kinase (MAPK) pathways and protein sumoylation. in The Journal of biological chemistry 2012
Systems approach revealed that histone deacetylation is strongly associated with the suppression of EP300 target genes implicated in diabetes.
novel EP300 mutations were found in Rubinstein-Taybi 2 syndrome
p300 autoacetylation is associated with tongue neoplasms.
CREBBP and p300 may contribute to genome stability by fine-tuning the functions of DNA damage signaling and DNA repair factors, thereby expanding their role as tumor suppressors. (Review)
Results show that p300 recruitment along with binding to histones are required for cMyb to fully activate transcription of a chromatinembedded gene.
Our data show that the hyperacetylation of Tau by p300 histone acetyltransferase (HAT) disfavors liquid-liquid phase separation , inhibits heparin-induced aggregation, and impedes access to LLPS-initiated microtubule assembly
EP300 variants are associated with Rubinstein-Taybi syndrome.
High P300 expression is associated with recurrence in prostate cancer.
Data generated with primary human hepatic stellate cells (HSC) supports that stiffness-mediated HSC activation requires p300.
The histone acylation activity of p300 can be activated by pre-existing lysine crotonylation through a positive feedback mechanism.
epigenomic profiling of clear cell renal cell carcinoma (ccRCC) establishes a compendium of somatically altered cis-regulatory elements, uncovering new potential targets including ZNF395. Loss of VHL, a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a and recruitment of histone acetyltransferase p300 at preexisting lineage-specific promoter-enhancer complexes
Histone acetyltransferase EP300 is necessary for the transcription factor SOX2 activity in basal cells, including for induction of the squamous fate. EP300 copy number gains are common in squamous cell carcinoma SQCCs, including lung cancer SQCC cell lines.
High expression of EP300 is associated with colorectal cancer.
Transcriptional coactivator p300 gene polymorphism correlates with the development and advancement of diabetic kidney disease. Additionally, the SIRT1 gene collaborates with the p300 gene and participates in promoting albuminuria in type 2 diabetes mellitus patients.
These results reveal a novel RTK-AKT-p300-ADA3 signaling pathway involved in growth factor-induced cell cycle progression.
Study suggest that both p300 and CREB are required for the function integrity of HIF-1alpha transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300, CREB and HIF-1alpha.
These results suggest that EP300 harbors adaptive variants in Tibetans, which might contribute to high-altitude adaptation through regulating NO production.
EP300 plays a major role in the reprogramming events, leading to a more malignant phenotype with the acquisition of drug resistance and cell plasticity, a characteristic of metaplastic breast cancer.
E-cadherin expression was increased by transfection of p300 small interfering RNA in a dose-dependent manner.. There was a correlation between Snail and p300 expressions in lung cancer. Moreover, p300 acetylates Snail both in vivo and in vitro, and K187 may be involved in this modification.
Two possible modes of pioneering associated with combinations of H2A.Z and p300/CBP at nucleosome-occupied enhancers.
Study in mouse model found that liver stiffness activates hepatic stellate cells differentiation into myofibroblasts, which required nuclear accumulation of p300.
Data (including data from studies in knockout and transgenic mice) suggest that Ep300 and Crebbp are limiting cofactors for pancreatic islet development (including gene expression regulation and cell proliferation), and hence for postnatal glucose homeostasis, with some functional redundancy. (Ep300 = E1A binding protein p300; Crebbp = CREB binding protein)
Here the authors report a lipopolysaccharide-induced NFkappaB enhanceosome in which TonEBP is required for the recruitment of p300. Increased expression of TonEBP enhances the NFkappaB activity and reduced TonEBP expression lowers it.
Enhancer-priming by MLL3/MLL4 followed by enhancer-activation by CBP/p300 sequentially shape dynamic enhancer landscapes during cell differentiation
Data show that LPS induces endoplasmic reticulum (ER) stress and P300 activity via the XBP1/IRE1 pathway.
Loss of p300 expression is associated with leukemogenesis.
UTX-MLL4-p300 transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 and HDAC1-HDAC2 has been described.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 activity was necessary for c-Myc binding to acetyltransferase p300 in myeloid cells; Prmt1 inhibition decreases p300 recruitment to c-Myc target promoters and increased Hdac1 recruitment. [Prmt1, protein arginine N-methyltransferase 1; c-Myc = Proto-Oncogene Proteins c-myc; Hdac1 = histone deacetylase 1]
In line with the acetyltransferase activity of p300, H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC activity maintains PTGES1 expression by recruiting p300 to its gene
ARX positively regulates Wnt/ beta-catenin signaling and the C-terminal domain of ARX interacts with the armadillo repeats in beta-catenin to promote Wnt/beta-catenin signaling. In addition, we found BCL9 and P300 also interact with ARX to modulate Wnt/beta-catenin signaling.
2-O, 3-O desulfated heparin inhibited HMGB1 release, at least in part, by direct molecular inhibition of p300 HAT activity.
work shows that helenalin acetate inhibits C/EBPbeta by binding to the N-terminal part of C/EBPbeta, thereby disrupting the cooperation of C/EBPbeta with the co-activator p300.
STAT6 mediates the CT-induced TIM4 expression in DCs. In conclusion, p300 and STAT6 mediate the microbial product CT-induced TIM4 expression in DCs.
Findings indicate that E1a-binding protein (p300) is not required for the normal development or functioning of skeletal muscle.
Hdac3 cooperates with p300 to prime and maintain oligodendrocyte identity
p300 histone acetyltransferase activity is critical for Wnt-dependent palate mesenchymal cell proliferation and migration, both processes that play a significant role in morphogenesis of the palate.
Data indicate that glucose-induced endothelial to mesenchymal transition in vivo and in vitro in the hearts of diabetic mice is possibly mediated by miR-200b and p300.
This study demonstrated that p300 increase in skeletal muscle in muscle atrophy.
This study demonstrates that p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease.
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT