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Therefore, the current findings indicate that Noxa is a novel regulator of early mitosis before 75% epiboly stage when it translates into a key mediator of apoptosis in subsequent embryogenesis.
Fluorizoline increased the protein levels of the pro-apoptotic B-cell lymphoma 2 family member NOXA in chronic lymphocytic leukemia cells. Furthermore, fluorizoline synergized with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax to induce apoptosis.
By ubiquitylating and degrading NOXA through activating CRL5, UBE2F (zeige UBE2F Proteine) selectively promotes lung cancer cell survival and could, therefore, serve as a novel cancer target
Data show that Noxa-mediated MCL-1 (zeige MCL1 Proteine) phosphorylation and degradation is regulated by CDK2 (zeige CDK2 Proteine).
the c-FLIP (zeige CFLAR Proteine) and NOXA/Mcl-1 (zeige MCL1 Proteine) axis participated in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells
Noxa is involved in X-ray-induced lung injury.
Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and acts synergistically with antimicrotubule drugs.
knockdown of MCL-1 (zeige MCL1 Proteine) in MRT cell lines induced apoptosis and increased DOX sensitivity in malignant rhabdoid tumor cells
high levels of miR21 expression may induce gastric cancer migration and invasion via the downregulation of Noxa expression
Inhibition of SIRT1 (zeige SIRT1 Proteine) could induce the Noxa expression in A549/DDP (zeige TIMM8A Proteine) cells.
Fluorizoline bind to prohibitin (zeige PHB Proteine), inducing mitochondrial apoptotic pathway through NOXA and BIM (zeige BCL2L11 Proteine) upregulation.
data suggest that in the context of CLL NOXA may function as an oncomodulator
knockdown of pmaip1 mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.
In vivo upregulation of noxa was reduced by pifithrin-alpha, suggesting transcription may be partly p53 (zeige TP53 Proteine)-dependent.The present findings indicate Noxa does not serve as a proapoptotic BH3-only protein (zeige BAD Proteine) during seizure-induced neuronal death in vivo
In addition, studies in leukemia Jurkat T cells support the existence of the Sall2 (zeige SALL2 Proteine)/Noxa axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells.
Our data demonstrate that ES cells are uniquely sensitive to CDK1 (zeige CDK1 Proteine) inhibition via a p53 (zeige TP53 Proteine)/NOXA/MCL1 (zeige MCL1 Proteine) pathway.
Overall, these data reveal a Noxa-mediated signaling pathway that couples lysosomal membrane permeabilization with mitochondrial outer membrane permeabilization and ultimate apoptosis during oxidative stress.
by preventing the consumption of IL-15 (zeige IL15 Proteine), Bim (zeige BCL2L11 Proteine) limits the role of Noxa and Puma (zeige BBC3 Proteine) in causing the death of effector cells with less memory potential.
Induction of noxa does not influence ischemic neuronal injury.
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
phorbol-12-myristate-13-acetate-induced protein 1
, PMA-induced protein 1
, adult T cell leukemia-derived PMA-responsive
, immediate-early-response protein APR
, protein Noxa